Telomere Timebombs: Defusing the Terror of Aging by Park MD Ed

Author:Park MD, Ed
Language: eng
Format: azw3
Tags: telomerase, disease, telomeres, longevity, TA-65, anti-aging
Publisher: Ed Park, MD
Published: 2013-07-28T16:00:00+00:00

Arthritis

One of the hallmarks of aging, whether in “normal” people or in the accelerated aging of children, is osteoarthritis, or the degeneration of the cushioning cartilage at the surfaces where bone meets bone.

Harbo et al in Arthritis Research and Therapy (2012) studied arthritis using a methodology that ignores white blood cells (the tire tread). They looked at cartilage from real human knees and characterized the damage as you got farther from the central lesion. As we would predict from our knowledge of stem cell biology and niches, the closer you were to the central lesion (or the sickest of the hives) the worse was the arthritis, the more senescent were the cells, the shorter were the telomeres, and the higher was the percentage of critically-short telomeres. Critically-short telomeres are sometimes defined as those with less than 1500 base pairs, a possible threshold equivalent to being functionally naked or uncapped.

But was this statistically significant? Absolutely! In fact, the statistical probability of randomly finding these differences in the 21 patients studied was 1 in a million for arthritis grade, 2 in a million for senescence, 4 in a million for telomere length, and 7 in a thousand for critically-short telomeres.

For more information on arthritis, see Podcast 30 on my YouTube channel, “drpark65.”

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